News

In our news section, we not only provide the latest updates and analysis on advancements and trends in biotechnology, but we also highlight our own events that we organize for the scientific and professional community. Here you will find news about conferences, seminars, and workshops that we organize, focused on crucial topics such as the use of bioreactors, tangential flow filtration, and bioprocess supplies.

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Scalability validation, oxygen transfer (kLa) and power input (P/V)

Volumetric Mass Transfer Coefficient (kLa)

The volumetric mass transfer coefficient (kLa) was measured at varying tip speeds, using a constant aeration rate of 0.10 vvm (air) in PBS at 37 °C to assess oxygen transfer efficiency. Results demonstrated consistent scalability across bioreactor sizes:

At lower tip speeds (0.3 m/s), kLa values were comparable across all scales (0.3-0.6 h-1).

At increased tip speeds (1.8 m/s), the STR300 exhibited the highest kLa (25.3 h-1), while the STR50 and SU 0.5L reactors showed the lowest values (18.0-19.0 h-1).

This indicates suitable oxygen transfer rates (>7 h-1) were achieved across all bioreactor scales, enabling efficient cell cultivation.

Power Input per Volume (P/V)

Power input per volume, vital for mixing and gas dispersion, was analyzed across varying tip speeds:

At lower agitation speeds (0.3 m/s), the SU 0.5L reactor required significantly higher power input (1514 W/m3) compared to larger reactors (1-3 W/m3).

At higher speeds (1.8 m/s), power input dramatically increased for the SU 0.5L system (326,925 W/m3), whereas larger scales (STR1000, STR300, STR50, and STR30) showed lower and comparable power inputs (261-552 W/m3).

This trend indicates a scalable power input strategy, ensuring sufficient agitation for effective cell culture at larger scales without excessive energy consumption.

Our single-use bioreactors deliver the oxygen-transfer and mixing performance required for today’s cell-culture processes. They are engineered to support high-cell-density CHO applications while keeping critical parameters on setpoint. The same design principles apply from development vessels to larger units, making scale-up direct and predictable.

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